Tottenham striker Peter Crouch is out of England's squad for the Euro 2012 qualifiers against Bulgaria at Wembley on Friday and Switzerland next Tuesday.
Crouch has been ruled out with a back injury and will not be replaced.
Goalkeepers Ben Foster (knee) and Scott Carson (back) missed Tuesday's training and 19-year-old Arsenal reserve keeper James Shea had to make up the numbers.
Everton's Phil Jagielka, who had been expected to play at centre-back, missed training with an ankle injury.
Manchester City's Joe Hart is coach Fabio Capello's first-choice goalkeeper, but injuries to his deputies may lead to a repeat of the friendly win against Hungary on 11 August when Watford's Under-21 keeper Scott Loach and Blackburn's fourth-choice stopper Frankie Fielding were drafted in.
Goalkeeping options for Capello are fairly limited, with Paul Robinson having retired from the international stage, former first choice Rob Green awaiting a hip operation and Chris Kirkland dropped by his club Wigan after conceding 10 goals in the club's first two league matches.
England's squad is much changed from the disappointment of their World Cup campaign in South Africa earlier in the summer.
David James and Ledley King have been discarded by the England boss, while Liverpool stalwart Jamie Carragher has announced his international retirement.
Spurs winger Aaron Lennon has not featured in either squad since the World Cup, but the latest omission is thought to be because of concerns over an ankle injury.
In addition, Chelsea duo John Terry and Frank Lampard have been ruled out because of injury, Terry sidelined by a hamstring problem and Lampard missing the match to have a hernia operation.
Should Jagielka be ruled out of contention against Bulgaria, Bolton's Gary Cahill could be in line for a senior debut, with Spurs defender Michael Dawson another candidate, having made his first appearance as a substitute in the 2-1 friendly win over Hungary earlier in August.
One man left out of the World Cup squad who is now firmly back in favour is Arsenal's Theo Walcott, who is expected to start on Friday.
"I had a nice break through the summer and everything has gone well, so I just have to keep my feet on the ground," the 21-year-old said.
"It's one of those things," he added of his World Cup exclusion. "I didn't point the finger at anyone, I didn't blame anyone, it's disappointing, but I'm not going to blame myself, I just want to make sure it doesn't happen again by working hard on the training pitch."
Looking ahead to Friday night's match he said: "No game is easy at international level, we had a good result against Hungary and we managed to play well for the whole game.
"Sometimes the goals don't go in because people come to Wembley, a fantastic fortress, and they put people behind the ball so it can be very difficult to break them down.
England also travel to Switzerland for another qualifier on Tuesday and also face Montenegro and Wales in qualifying Group G, ahead of the 2012 finals in Poland and Ukraine.
Onto the tennis and some pretty weird and wonderful results with a lot of form players getting beaten or struggling. A lot of talk about Gulbis and Berdych being the new breed but both getting beaten fairly easily along with Baggy. Then Fish who really has been playing well getting into all sorts of trouble with Hajek. This game was perfect for me as starting at 1.04 Fish was simply to low against a top 100 player. Again the recent form was taken into too much context, it isnt as overnight he had become Roger Federer.
As the draw gets more organised I will have a few wagers but I really cant see past Murray. Maybe someone less expected like Davydenko or Roddick might be the way to go.
Today was a loser as the horse lays which were looking good got a hit and all five bets I had didnt place. So starting off the month with a £ 250 total loss.